Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Gomes AP, Price NL, Ling AJ, et al. · Cell

The study behind the popular NMN-for-aging framing, from David Sinclair's laboratory: one week of injected NMN in 22-month-old mice restored skeletal-muscle NAD+ and mitochondrial function toward youthful levels in a SIRT1-dependent manner. Muscle, not cartilage; injected, not swallowed.

Population

Young and 22-month-old mice; skeletal muscle analyses

Intervention

NMN 500 mg/kg/day by intraperitoneal injection for 7 days

Comparator

PBS-injected littermates; young mice

Limitations

Intraperitoneal dosing at levels far above human oral supplementation; no joint tissue examined; mouse. Full text read for the dosing regimen.