Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study

Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. · Clinical Interventions in Aging

Turmeric extract was non-inferior to ibuprofen on WOMAC pain and function at 4 weeks, with significantly fewer abdominal pain/GI adverse events in the curcumin group.

Population

Adults with knee osteoarthritis, Thailand

Intervention

Curcuma domestica (turmeric) extract 1500 mg/day for 4 weeks

Comparator

Ibuprofen 1200 mg/day (no placebo arm)

Limitations

No placebo arm; only 4 weeks; government-funded but extract standardization differs from Western products.