Effects of pentosan polysulfate in osteoarthritis of the knee: A randomized, double-blind, placebo-controlled pilot study

Ghosh P, Edelman J, March L, et al. · Current Therapeutic Research, Clinical and Experimental

Significant improvements vs placebo in stiffness duration, pain at rest, and patient global assessment, with some functional gains persisting 8–12 weeks after the last dose.

Population

Adults with knee osteoarthritis, mean age 63

Intervention

Sodium PPS 3 mg/kg IM weekly for 4 weeks

Comparator

Ringer's solution injection

Limitations

Pilot-scale; lead author held PPS-related commercial interests; never followed by an independent confirmatory trial of the IM regimen.