Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials

Liu K, Zhou R, Wang B, Mi MT · The American Journal of Clinical Nutrition

Resveratrol significantly lowered fasting glucose, insulin, HbA1c and HOMA-IR in participants with diabetes, and had no significant effect on any glycaemic measure in non-diabetic participants — the split that explains why the healthy-volunteer trials keep coming back null.

Population

388 participants across 11 randomised trials, diabetic and non-diabetic

Intervention

Resveratrol at a range of doses and durations

Comparator

Placebo

Limitations

Eleven small trials; the diabetic subgroup rests on a handful of studies, several from the same regions and groups. Later umbrella review graded most of these effects as trivial in magnitude and low in certainty.