Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Two-Year Follow-up of a Prospective Randomized Trial

Saris D, Price A, Widuchowski W, et al. · The American Journal of Sports Medicine

MACI produced significantly greater improvement in KOOS pain and function than microfracture at 2 years.

Population

Adults with symptomatic knee cartilage defects ≥3 cm² (SUMMIT trial)

Intervention

MACI (matrix-applied characterized autologous cultured chondrocytes)

Comparator

Microfracture

Limitations

Open-label surgical trial; sponsor-funded; defects ≥3 cm² only.