Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts

Chang CH, Tsai WC, Hsu YH, Pang JH · Molecules

The group's earlier cDNA microarray had identified the growth hormone receptor as one of the most strongly upregulated genes; here BPC 157 raised it dose- and time-dependently at mRNA and protein level, and adding growth hormone then increased fibroblast proliferation and PCNA expression with time-dependent JAK2 activation.

Population

Tendon fibroblasts isolated from rat Achilles tendon

Intervention

BPC 157 at graded concentrations, with and without added growth hormone

Comparator

Untreated cells

Limitations

Cell culture only; an independent Taiwanese group (Chang Gung University), but the receptor-upregulation finding has not been reproduced in vivo. Supported by Taiwan's National Science Council and Chang Gung Memorial Hospital; no conflicts declared.