The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study

Shea MK, Kritchevsky SB, Hsu FC, et al. · Osteoarthritis and Cartilage

Very low plasma vitamin K (<0.2 nM) was associated with greater progression of MRI cartilage damage (OR 1.7) and meniscus damage (OR 2.6) over 3 years vs sufficient levels.

Population

Community-dwelling older adults (Health ABC), 3-year MRI follow-up

Intervention

Plasma phylloquinone and dephosphorylated-uncarboxylated MGP measured; no intervention

Comparator

Plasma phylloquinone >=1.0 nM (sufficient)

Limitations

Observational; ORs have wide intervals; K1 as status marker; no K2 exposure data.