Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial

Panahi Y, Alishiri GH, Parvin S, Sahebkar A · Journal of Dietary Supplements

Serum superoxide dismutase activity rose (mean change 2.94 vs -0.38, p<0.001) and malondialdehyde fell (-5.26 vs -2.49, p=0.044) versus placebo; glutathione was borderline (p=0.064).

Population

Adults with mild-to-moderate knee osteoarthritis, Iran (the pmid-24853120 cohort)

Intervention

Curcuminoids 1500 mg/day plus piperine 15 mg/day, 6 weeks

Comparator

Matched placebo

Limitations

Third report from the same 40-patient pilot; surrogate endpoints only, and the parallel inflammatory-marker report from this cohort was null between groups (pmid-25050518).