Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer

Comblain F, Sanchez C, Lesponne I, Balligand M, Serisier S, Henrotin Y · PLoS One

Curcuminoid extract cut IL-6, iNOS, COX-2, MMP-3, ADAMTS-4 and ADAMTS-5 expression in IL-1beta-stimulated cells, and the three-compound mixture suppressed MMP-3 more than curcuminoids alone.

Population

Normal bovine and osteoarthritic human chondrocytes in monolayer, with and without IL-1beta

Intervention

Curcuminoid extract alone or combined with hydrolysed collagen and green tea extract

Comparator

Untreated and IL-1beta-only controls

Limitations

Monolayer culture with no matrix, and the study was funded by Royal Canin (pet nutrition) with company co-authors; the combination has not been tested in a human joint.