Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

Huang T, Zhang K, Sun L, Xue X, Zhang C, Zhang Y, Zhang W, et al. · Drug Design, Development and Therapy

Faster wound closure with better granulation, re-epithelialisation and collagen deposition at day 18, raised VEGF in wounded skin, and in culture increased HUVEC proliferation, migration and tube formation via ERK1/2 with c-Fos, c-Jun and Egr-1 downstream.

Population

Rat alkali-burn skin wounds, plus human umbilical vein endothelial cells

Intervention

Topical BPC-157

Comparator

Untreated model controls

Limitations

Independent Chinese military-medical group; skin rather than musculoskeletal tissue, and closure scored without blinding.