Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics

Natarajan V, Madhan B, Tiku ML · PLoS One

Protection of articular cartilage from inflammatory degradation, and the authors frame the result as an argument for polyphenols as an injected cartilage therapeutic rather than as a dietary one.

Population

Animal joints with inflammation-induced cartilage degradation

Intervention

Polyphenols injected intra-articularly

Comparator

Vehicle

Limitations

Intra-articular delivery; the framing itself concedes that the dietary route is the problem.