Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial

Görmeli G, Görmeli CA, Ataoglu B, et al. · Knee Surgery, Sports Traumatology, Arthroscopy

All active groups beat saline on IKDC/EQ-VAS at 6 months; three PRP injections outperformed single PRP and HA in early OA. No between-treatment differences in advanced OA.

Population

Adults with knee OA stratified into early (KL 0-III) and advanced (KL IV) disease

Intervention

Three PRP injections or one PRP injection

Comparator

One HA injection or saline

Limitations

6-month follow-up only; single center; benefit confined to early OA.