[POLYPEPTIDES INFLUENCE ON TISSUE CELL CULTURES REGENERATION OF VARIOUS AGE RATS]

Ryzhak AP, Chalisova NI, Lin'kova NS, Khalimov RI, Ryzhak GA, Zhekalov AN · Advances in Gerontology (Uspekhi Gerontologii)

Each extract stimulated growth of the culture from its own source tissue at 20–50 ng/ml, with PCNA rising and p53 falling in cartilage among others — a tissue-specificity result, not a repair or matrix result.

Population

Organotypic tissue cultures from young and old rats, including cartilage

Intervention

Seven calf-tissue polypeptide extracts at 0.01–100 ng/ml, including Chondrolux (from cartilage), the closest indexed sibling of Sigumir

Comparator

Untreated cultures of the same tissue

Limitations

Institute-authored; Russian-language institute-linked journal; explant growth-zone and immunocytochemistry endpoints with no numbers in the indexed abstract; Chondrolux is a sibling product, not Sigumir itself.