The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials

Al-Karawi D, Al Mamoori DA, Tayyar Y · Phytotherapy Research

Curcumin reduced depression symptoms (SMD -0.34, 95% CI -0.56 to -0.13, p=0.002), with larger effects at higher doses and longer durations. The BCM-95 formulation performed non-significantly better than the conventional curcumin-piperine combination.

Population

6 clinical trials in patients with major depressive disorder

Intervention

Curcumin administration

Comparator

Placebo or control

Limitations

Six small trials, most from a single research group, with a modest pooled effect; the formulation comparison is underpowered and indirect.