Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial

Jin X, Jones G, Cicuttini F, et al. · JAMA

NULL on both primary endpoints: no significant difference in annual tibial cartilage volume loss or WOMAC pain change over 2 years, despite correcting deficiency.

Population

Adults with symptomatic knee OA AND low serum 25(OH)D (Tasmanian VIDEO trial); 209 vitamin D, 204 placebo

Intervention

Vitamin D3 50,000 IU once monthly for 2 years

Comparator

Placebo

Limitations

Monthly bolus dosing rather than daily; 2-year window may be short for structural change.