NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P · Science

NR rejuvenated muscle, neural and melanocyte stem cells via the mitochondrial unfolded protein response and modestly increased mouse lifespan — the most-cited demonstration that an oral NAD+ precursor can extend life in a mammal.

Population

Aged and dystrophic mice

Intervention

Nicotinamide riboside

Comparator

Untreated

Limitations

Mouse; treatment started late in life and the lifespan gain was modest. NR, not NMN.