Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro

Lin'kova NS, Drobintseva AO, Orlova OA, et al. · Bulletin of Experimental Biology and Medicine

AED reduced MMP-9 synthesis, increased proliferation markers, and suppressed apoptosis in aging fibroblasts — skin cells, not chondrocytes.

Population

Aging cultured human skin fibroblasts

Intervention

Short peptides including AED (the Cartalax tripeptide) and AEDG

Comparator

Untreated aging cultures

Limitations

Khavinson-institute lab; fibroblast model with no cartilage relevance; no independent replication.