The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial

Arden NK, Cro S, Sheard S, et al. · Osteoarthritis and Cartilage

NULL: no difference in the rate of medial joint space narrowing over 3 years (-0.01 vs -0.08 mm/year; difference 0.08 mm/year, 95% CI -0.14 to 0.29, P=0.49); no meaningful symptom benefit.

Population

UK adults with radiographic knee OA, 3-year trial (VIDEO study)

Intervention

Cholecalciferol 800 IU/day for 3 years

Comparator

Placebo

Limitations

800 IU/day is a low dose; participants not required to be deficient at baseline; radiographic JSN is an insensitive outcome.