Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis

Abusarah J, Benabdoune H, Shi Q, Lussier B, Martel-Pelletier J, Malo M, Fernandes JC, de Souza FP, Fahmi H, Benderdour M · Journal of Cellular Biochemistry

Supplies the chondrocyte-level mechanism the symptom trials lack: 6-gingerol reduced catabolic and oxidative markers in osteoarthritic chondrocytes and was protective in the animal model.

Population

Osteoarthritic chondrocytes and an animal model of osteoarthritis

Intervention

6-gingerol, the principal pungent constituent of ginger, and the antioxidant formulation Protandim

Comparator

Untreated

Limitations

Cell and animal work at concentrations set by the experimenters, and 6-gingerol in isolation is not the multi-constituent extract used in the trials.