The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice

Park JR, Lee H, Kim SI, Yang SR · Oncotarget

Lowered reactive oxygen species, TNF-α and IL-6 and raised superoxide dismutase activity through suppression of NF-κB p65 and p38 MAPK, and reduced inflammatory-cell infiltration and histological injury in the lung.

Population

Mice with LPS-induced acute lung injury, and RAW 264.7 macrophages

Intervention

GHK-Cu

Comparator

LPS alone

Limitations

Acute lung injury, not joint tissue. One author is affiliated with Bioceltran Co., Ltd., a peptide company.