Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial

Mozaffari-Khosravi H, Naderi Z, Dehghan A, Nadjarzadeh A, Fallah Huseini H · Journal of Nutrition in Gerontology and Geriatrics

TNF-α and IL-1β did not differ between groups at baseline and both were lower in the ginger group at 3 months — the mechanistic counterpart to the symptom trials, in the one study that measured it over a useful duration.

Population

Older adults with knee osteoarthritis

Intervention

500 mg ginger powder daily for 3 months

Comparator

500 mg starch placebo, double-blind

Limitations

Biomarker endpoints only; the trial reports cytokine change without an accompanying clinical outcome in its abstract. Ginger powder at 500 mg/day is a different exposure from the concentrated extracts used in the symptom trials.