Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation

Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS · Journal of Molecular Medicine

Vessel density rose in the membrane assay and in endothelial tube formation, hindlimb blood flow recovered faster on laser Doppler, and BPC 157 raised VEGFR2 mRNA and protein — but not VEGF-A — and drove receptor internalisation with VEGFR2–Akt–eNOS activation, all of it abolished by blocking endocytosis.

Population

Chick chorioallantoic membrane, human vascular endothelial cells, and rat hindlimb ischaemia

Intervention

BPC 157, with and without the endocytosis inhibitor dynasore

Comparator

Vehicle

Limitations

Mechanistic, not an injury-repair endpoint; independent of the Zagreb network but from the same Chang Gung group as the tendon-fibroblast work.