Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y · Cell Metabolism

Twelve months of oral NMN suppressed age-related weight gain, raised energy expenditure and physical activity, improved insulin sensitivity and plasma lipids, and preserved eye function, with no observed toxicity. Lifespan itself was not the endpoint and was not extended as a reported result.

Population

Wild-type C57BL/6N mice on regular chow through normal ageing

Intervention

Oral NMN in drinking water for 12 months

Comparator

Untreated littermates

Limitations

Mouse; no joint or cartilage measurement among the endpoints. The doses used scale well above typical human supplementation, and the senior author holds commercial interests in NMN.