Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Butawan M, Benjamin RL, Bloomer RJ · Nutrients

Summarizes evidence that MSM dampens NF-kB signalling and oxidative stress in preclinical models and is well tolerated in humans (GRAS status; trials up to ~6 g/day report adverse events comparable to placebo).

Population

Narrative review of MSM pharmacology, mechanisms, and safety

Intervention

MSM at doses up to about 4 g/day in humans; mechanistic data from cell and animal models

Comparator

n/a

Limitations

Narrative review; mechanistic claims rest largely on in-vitro and animal data.