GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis

Wang X, Liu B, Xu Q, Sun H, Shi M, Wang D, Guo M, Yu J, Zhao C, Feng B · Wound Repair and Regeneration

Liposomal GHK-Cu raised endothelial proliferation by 33.1%, increased VEGF, FGF-2, CDK4 and cyclin D1, produced better angiogenesis than free GHK-Cu on CD31 and Ki67 staining, and shortened healing to 14 days.

Population

Mouse scald model, with human umbilical vein endothelial cells in vitro

Intervention

Liposome-encapsulated GHK-Cu

Comparator

Free GHK-Cu and untreated wounds

Limitations

Burn model; the comparison that works is formulation against formulation, so the result is as much about liposomal delivery as about the peptide.