[OPTIMIZATION OF REPARATIVE OSTEOGENESIS JAWS ON AGING (PRECLINICAL STUDIES)]

Slugina AS, Iordanishvili AK, Serikov AA, Samsonov VV, Ryzhak GA · Advances in Gerontology (Uspekhi Gerontologii)

Starting Cartalax 30 days before surgery produced, at 60–120 days, a regenerate with less connective and cartilaginous tissue and more advanced remodelling of new bone than in controls or in animals dosed only from the day of surgery. This is the only indexed animal study of Cartalax.

Population

Old rats with a standardised post-surgical bone cavity in the mandible

Intervention

Kartalaks (Cartalax) started either 30 days before surgery or at the time of surgery

Comparator

Untreated old rats

Limitations

Histology and morphometry only, with no group sizes or numbers in the indexed abstract; jaw-bone healing is not articular cartilage; Russian-language institute-linked journal.