Matrix-Assisted Autologous Chondrocyte Transplantation in the Knee: A Systematic Review of Mid- to Long-Term Clinical Outcomes

Schuette HB, Kraeutler MJ, McCarty EC · Orthopaedic Journal of Sports Medicine

At 5+ years outcomes remained improved; overall treatment failure 9.7% (12.4% tibiofemoral, 4.7% patellofemoral).

Population

578 patients (442 tibiofemoral, 136 patellofemoral defects) across 10 studies with minimum 5-year follow-up

Intervention

Matrix-assisted ACI (MACI and equivalents)

Comparator

None (pooled single-arm outcomes)

Limitations

Mostly case series pooled; heterogeneous scaffolds and outcome measures.