Mitochondrial dysfunction is an acute response of articular chondrocytes to mechanical injury

Delco ML, Bonnevie ED, Bonassar LJ, Fortier LA · Journal of Orthopaedic Research

Impact caused mitochondrial depolarization and impaired respiratory function within 2 hours of injury — before widespread cell death — identifying mitochondrial dysfunction as one of the earliest measurable chondrocyte responses to cartilage trauma.

Population

Neonatal bovine cartilage explants from weight-bearing and non-weight-bearing sites of 10 knees

Intervention

Single rapid impact injury (5-17 MPa, 5-34 GPa/s)

Comparator

Non-impacted explants

Limitations

Neonatal bovine explants; no treatment tested — characterizes the injury response that SS-31 is later aimed at.