Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis

Javaheri B, Poulet B, Aljazzar A, de Souza R, Piles M, Hopkinson M, Shervill E, Pollard A, Chan B, Chang YM, Orriss IR, Lee PD, Pitsillides AA · Bone

Gait abnormalities were reduced and subchondral bone microarchitecture altered. Valuable because the model is spontaneous — no joint was cut to start the disease, which removes the acute-injury confound present in DMM and ACLT work.

Population

STR/Ort mice, which develop osteoarthritis spontaneously rather than by surgery

Intervention

Stabilized sulforaphane

Comparator

Untreated STR/Ort mice

Limitations

Mouse. The primary readouts are gait and bone architecture rather than cartilage histology, and stabilized sulforaphane is a formulated compound, not broccoli.