Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

Drmic D, Kolenc D, Ilic S, Seiwerth S, Sikiric P, et al. · World Journal of Gastroenterology

BPC 157 counteracted gastric, liver and brain lesions and the rise in liver enzymes at 24 h and 48 h, and did so whether or not nitric-oxide synthase was blocked, while L-arginine's benefit was blunted by L-NAME — a dissociation the authors read as BPC 157 acting on the NO system rather than through it.

Population

Rats given celecoxib 1 g/kg i.p.

Intervention

BPC 157 10 µg, 10 ng or 1 ng/kg i.p. immediately after celecoxib

Comparator

L-arginine 100 mg/kg, L-NAME 5 mg/kg, and combinations

Limitations

Originating network; 1 g/kg is far above any clinical exposure, and lesion scoring is the primary endpoint.