Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside

Chin KY, Pang KL · Nutrients

The reference survey of the topic. It finds a consistent benefit across animal studies and attributes the chondroprotection to two mechanisms — augmented autophagy via sirtuin-1 and suppressed inflammation — while stating that the clinical trials needed to justify olive-based treatment have not been done.

Population

Animal and human studies of olive and olive derivatives in osteoarthritis and chondrocytes

Intervention

Olive oil, olive leaf extract, and isolated olive polyphenols

Comparator

Varies

Limitations

Narrative review, no pooling or risk-of-bias appraisal, and its 'bedside' half is thinner than its title suggests.