Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation: Two-Year Follow-up

López-Alcorocho JM, Aboli L, Guillen-Vicente I, et al. · Cartilage

At 24 months, IKDC improved by a mean 31 points with significant reductions in pain and swelling; no comparator arm, so no evidence of superiority over standard MACI.

Population

50 patients with knee cartilage defects treated at Clínica CEMTRO, Madrid, with high-density ACI (5 million cells/cm²)

Intervention

High-density autologous chondrocyte implantation (HD-ACI / Instant Cemtrocell)

Comparator

None

Limitations

Single-center uncontrolled case series by the technique's developers; no comparison to conventional-density ACI in humans.