Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation: Two-Year Follow-up

López-Alcorocho JM, Aboli L, Guillen-Vicente I, et al. · Cartilage

At 24 months IKDC improved by a mean 31.0 points (95% CI 22.9 to 39.0), having been 26.3 points at 12 months, with significant reductions in pain (P < 0.001) and swelling (P = 0.040).

Population

50 patients with knee cartilage defects treated at Clínica CEMTRO, Madrid, with high-density ACI (5 million cells/cm²)

Intervention

High-density autologous chondrocyte implantation (HD-ACI / Instant Cemtrocell)

Comparator

None

Limitations

Single-center uncontrolled case series by the technique's developers; no comparison to conventional-density ACI in humans.