Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women

Ruff KJ, Morrison D, Duncan SA, et al. · Clinical Interventions in Aging

NEM reduced exercise-induced stiffness versus placebo and lowered the urinary cartilage-degradation biomarker CTX-II both at rest and after exercise; effects on exercise-induced pain were smaller and inconsistent across days.

Population

Healthy postmenopausal women performing a standardized exercise regimen

Intervention

NEM 500 mg once daily for 2 weeks alongside alternate-day exercise

Comparator

Placebo

Limitations

Manufacturer-sponsored with company author; healthy (non-OA) population; 2-week duration; CTX-II is a surrogate marker.