Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Five-Year Follow-up of a Prospective Randomized Trial

Brittberg M, Recker D, Ilgenfritz J, Saris DBF · The American Journal of Sports Medicine

The clinically and statistically significant advantage of MACI over microfracture in KOOS pain and function was maintained at 5 years.

Population

SUMMIT trial extension cohort (65 MACI, 63 microfracture)

Intervention

MACI

Comparator

Microfracture

Limitations

16 of 144 randomized patients not followed into the extension; sponsor-funded.