Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults

Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB · Nature Communications

NR was well tolerated and roughly doubled blood NAD+. Systolic blood pressure and aortic stiffness trended down without reaching significance in the whole group, which the authors framed as a hypothesis for larger trials rather than a result.

Population

Healthy middle-aged and older adults

Intervention

Nicotinamide riboside 1,000 mg/day for 6 weeks, crossover

Comparator

Placebo

Limitations

Thirty participants, six weeks per arm; the cardiovascular signals are exploratory and were not confirmed by the follow-up trial designed to test them.