A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline

Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC · Cell Metabolism

Blocking the NAD+-consuming enzyme CD38 reversed tissue NAD+ decline and improved glucose tolerance, muscle function, exercise capacity and cardiac function in aged mice; the benefits disappeared when NAD+ synthesis was blocked, tying them to NAD+ itself.

Population

Naturally aged and progeroid mice

Intervention

78c, a specific CD38 inhibitor

Comparator

Vehicle

Limitations

Mouse only; 78c is an experimental compound, not a supplement. Demonstrates that closing the drain works, which is a different intervention from swallowing precursor.