Pigmentary Maculopathy Associated with Chronic Exposure to Pentosan Polysulfate Sodium

Pearce WA, Chen R, Jain N · Ophthalmology

Described a novel pigmentary maculopathy in chronic oral PPS users — the safety signal that led to US label warnings for long-term Elmiron use.

Population

Adults on long-term oral PPS (Elmiron) for interstitial cystitis

Intervention

Chronic oral PPS exposure (median years of use)

Comparator

None

Limitations

Case series; risk appears tied to cumulative long-term oral exposure, and relevance to short injectable courses is unknown.