High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis

de Paz-Lugo P, Lupiáñez JA, Meléndez-Hevia E · Amino Acids

Glycine at or above 1.0 mM increased chondrocyte collagen synthesis by roughly 60-75%, more than proline or lysine enrichment, supporting the glycine-limitation hypothesis at the cell level.

Population

Cultured bovine articular chondrocytes

Intervention

Culture medium enriched with glycine, proline, or lysine at graded concentrations

Limitations

Bovine cells in a dish; culture glycine concentrations exceed normal human plasma levels; authors are the originators of the hypothesis being tested.