The Plasma NAD(+) Metabolome Is Dysregulated in "Normal" Aging

Clement J, Wong M, Poljak A, Sachdev P, Braidy N · Rejuvenation Research

Plasma NAD+, NADP+ and nicotinic acid adenine dinucleotide declined significantly with age, while the reduced forms (NADH, NADPH), nicotinamide and ADP-ribose rose. Plasma NMN itself showed no significant change with age.

Population

Healthy human volunteers aged 20-87 years

Intervention

None — LC-MS/MS quantification of the plasma NAD+ metabolome across age

Comparator

Age groups

Limitations

Cross-sectional; plasma is an extracellular compartment and need not track intracellular tissue NAD+, which is where the biology happens.