Dose-Related Antihypertensive Properties and the Corresponding Mechanisms of a Chicken Foot Hydrolysate in Hypertensive Rats

Mas-Capdevila A, Pons Z, Aleixandre A, et al. · Nutrients

The hydrolysate lowered systolic blood pressure at 55 and 85 mg/kg (-26 and -30 mmHg at 6 h, matching captopril) but not at 25 mg/kg, with plasma ACE activity 21% lower at 55 mg/kg and no effect in normotensive rats.

Population

Spontaneously hypertensive rats

Intervention

Chicken-foot protein hydrolysate (Hpp11) at 25, 55, or 85 mg/kg

Comparator

Water; captopril 50 mg/kg as positive control

Limitations

Rat study, at least six per group; outcome unrelated to joints; purified hydrolysate is not equivalent to eating chicken feet. Spanish government grants; the authors hold a patent application on the hydrolysate; no conflicts declared.