Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

Song Y, Li S, Geng W, et al. · Redox Biology

The same NAD+/SIRT3 logic in the spine's cartilaginous tissue: AGEs stress impaired SIRT3 and drove human disc-cell apoptosis; NMN restored SIRT3 function and rescued the cells via AMPK-PGC-1α, and protected against disc degeneration in a rat model.

Population

Human nucleus-pulposus (spinal disc) cells and a rat tail disc-degeneration model

Intervention

NMN, against advanced-glycation-end-product (AGEs) stress

Comparator

AGEs-stressed cells/discs without NMN

Limitations

Disc cells and a rat tail model, not articular cartilage; experimental dosing, not oral human supplementation.