Absorption and metabolism of isothiocyanates formed from broccoli glucosinolates: effects of BMI and daily consumption in a randomised clinical trial

Charron CS, Vinyard BT, Ross SA, Seifried HE, Jeffery EH, Novotny JA · The British Journal of Nutrition

How much sulforaphane a person gets from the same broccoli depends on the person. Plasma exposure and urinary excretion of isothiocyanate metabolites diverged by BMI: above a BMI of 26, daily broccoli lowered exposure relative to no habitual broccoli; below it, daily broccoli raised exposure. GSTM1 genotype did not explain the difference.

Population

Adults balanced for BMI and GSTM1 genotype

Intervention

200 g cooked broccoli plus 20 g raw daikon radish daily for 15 days

Comparator

The same diet with no broccoli

Limitations

n=18, healthy adults, cancer-prevention framing, no joint endpoint. Registered NCT02346812.