Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial

Di Martino A, Di Matteo B, Papio T, et al. · The American Journal of Sports Medicine

No significant intergroup difference in any clinical score at any follow-up through ~5 years; median duration of benefit ~12 months in both. Reintervention rate at 24 months was lower with PRP (22.6% vs 37.1%, P=.036).

Population

Same cohort as Filardo 2015; 167 reached final evaluation (mean 64.3 months)

Intervention

3 weekly leukocyte-rich PRP injections

Comparator

3 weekly HA injections (double-blind)

Limitations

No placebo arm; substantial attrition by 5 years; benefit in both arms waned over time.