Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Matas J, Orrego M, Amenabar D, et al. · Stem Cells Translational Medicine

Repeated UC-MSC dosing produced significantly lower WOMAC pain at 12 months than HA (1.1 vs 4.3, P=.04); single dosing was intermediate. No serious adverse events.

Population

26 patients with symptomatic knee OA (HA 8, single MSC dose 9, repeated MSC dose 9)

Intervention

Allogeneic umbilical cord-derived MSCs, single dose or repeated at 6 months

Comparator

Hyaluronic acid at baseline and 6 months

Limitations

Tiny arms; several authors employed by Cells for Cells (cell manufacturer); phase I/II.