NAD(+) metabolism governs the proinflammatory senescence-associated secretome

Nacarelli T, Lau L, Fukumoto T, Zundell J, Fatkhutdinov N, Wu S · Nature Cell Biology

Raising NAD+ through NAMPT amplified the pro-inflammatory senescence-associated secretory phenotype rather than suppressing it, and the authors concluded that anti-ageing dietary NAD+ augmentation 'should be administered with precision'.

Population

Senescent human and mouse cells; mouse tumour models

Intervention

Manipulation of NAMPT and NAD+ levels in senescent cells

Comparator

Unmanipulated senescent cells

Limitations

Cell and mouse work; whether oral precursor doses reach the concentrations used here in human tissue is unknown. Frequently omitted from supplement-side summaries of NAD+ biology.