High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects

López-Alcorocho JM, Guillén-Vicente I, Rodríguez-Iñigo E, et al. · Cartilage

At 24 months median VAS pain fell from 8 to 2 and AOFAS score rose from 39.5 to 90; biopsy showed hyaline-like matrix.

Population

24 patients with ankle (talar) osteochondral lesions treated with HD-ACI at Clínica CEMTRO

Intervention

High-density ACI

Comparator

None

Limitations

Small single-center uncontrolled series from the developing group, and the paper states its 24 patients were 'a sample of convenience' — the first consecutive cases meeting criteria with two years of follow-up.