A case of acute kidney injury secondary to black cherry concentrate in a patient with chronic kidney disease secondary to type 2 diabetes mellitus

Matout M, Halme AS, Wiseman J · CEN Case Reports

Acute kidney injury and metabolic disturbance that resolved when the concentrate was stopped. The authors attribute it to cyclooxygenase inhibition by anthocyanins — the same mechanism the benefit claims rest on — and note it is the second such report.

Population

One adult with diabetic chronic kidney disease self-treating a gout flare

Intervention

Black cherry concentrate

Comparator

None

Limitations

A single case with no rechallenge, in an 88-year-old on an ACE inhibitor, an angiotensin receptor blocker and a thiazide-like diuretic, the triple combination the authors themselves name as the one that produces kidney injury with NSAIDs; the Naranjo score was 7 of 10. Concentrate delivers a dose of anthocyanins no one reaches by eating fruit, and pre-existing kidney disease is the condition it happened in.