The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD(+) decline

Chini C, Hogan KA, Warner GM, Tarragó MG, Peclat TR, Tchkonia T · Biochemical and Biophysical Research Communications

Senescent cells themselves did not express much CD38, but the factors they secrete raised CD38 expression and NADase activity in neighbouring non-senescent cells — a mechanism connecting accumulating senescent cells to falling tissue NAD+.

Population

Human endothelial cells and mouse bone-marrow-derived macrophages

Intervention

Exposure to conditioned medium from senescent cells

Comparator

Control medium

Limitations

In vitro; the link to whole-organism NAD+ decline is inferred rather than measured in tissue.