Slc12a8 is a nicotinamide mononucleotide transporter

Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K · Nature Metabolism

Reported that the Slc12a8 gene encodes a sodium-dependent transporter that carries intact NMN into cells, chiefly in the small intestine — the claim that NMN is taken up whole rather than first broken down to nicotinamide riboside.

Population

Mouse small intestine, plus cell lines

Intervention

Slc12a8 knockdown and isotope-traced NMN uptake

Comparator

Wild-type

Limitations

Mouse and cell work. The central claim was directly contested the following year (see pmid-32694648) and the paper carries a published author correction.