Effects of S-adenosylmethionine on human articular chondrocyte differentiation. An in vitro study

Harmand MF, Vilamitjana J, Maloche E, Duphil R, Ducassou D · The American Journal of Medicine

At 10 micrograms/mL, the most effective of the three doses, incorporation of 35S-sulfate and 3H-serine rose significantly and hexuronic acid content increased, which the authors read as more active protein synthesis and particularly proteoglycan synthesis. The proliferation rate of the chondrocytes did not change appreciably.

Population

Human osteoarthritic articular chondrocytes in thick-layer culture

Intervention

S-adenosyl-L-methionine at 1, 10 and 100 micrograms/mL

Limitations

Cultured cells from osteoarthritic cartilage, no mechanism identified — the authors say outright that little is known about how the effect is produced. It is the whole mechanistic case for SAMe reaching cartilage, and it is one 1987 culture experiment. Full text was not retrievable.